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Abilify 15 Mg

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seat: Asia-Pacific China
Validity to: Long-term effective
Last update: 2016-12-21 12:15
Browse the number: 63
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Antipsychotic (neuroleptic). It is assumed that the therapeutic effect of aripiprazole in schizophrenia due to a combination of partial agonist activity on dopamine D2-and serotonin 5HT1a receptors and antagonist activity at serotonin 5HT2-receptors.

Aripiprazole has a high affinity in vitro for dopamine D2-D3-and receptors, serotonin 5HT1a-and 5HT2a-receptors and moderate affinity for dopamine D4-, 5HT2c-and serotonin 5HT7-, α1-adrenoceptors and histamine H1-receptors.Aripiprazole is also characterized by a moderate affinity for the serotonin reuptake sites and no affinity for muscarinic receptors. In experimental animal studies, aripiprazole showed antagonism of dopaminergic hyperactivity and agonism against dopaminergic underactivity. Some clinical effects of aripiprazole may be explained by interaction with dopamine and serotonin receptors.

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